New, tolerable γ-secretase inhibitor takes desmoid down a notch.
نویسندگان
چکیده
A phase I trial of PF-03084014, an oral reversible γ-secretase inhibitor, in solid tumor malignancies shows drug tolerability in patients. Evidence of Notch pathway inhibition was demonstrated in peripheral blood. A surprisingly high rate of response was seen in desmoid tumors, a rare but sometimes locally aggressive sarcoma.
منابع مشابه
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عنوان ژورنال:
- Clinical cancer research : an official journal of the American Association for Cancer Research
دوره 21 1 شماره
صفحات -
تاریخ انتشار 2015